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DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL GIRK4 (GIRK4)
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL GIRK4 (GIRK4)
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机译:蛋白质内向整流钾通道蛋白4(GIRK4)引起的疾病的诊断和治疗
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摘要
The invention provides a human GIRK4 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GIRK4 as well as pharmaceutical compositions comprising such compounds.
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