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A KIND OF POLYSACCHARIDE, ITS PREPARATION METHOD AND USE

机译:一类多糖及其制备方法和用途

摘要

A kind of polysaccharide, which consists of glucose and glycuronic acid and does not comprise protein and nucleic acid, has molecular weight of 1.6x 106-2.6x 106Da, alpha-configuration end group carbon and optical rotation [α]Dt of +131.7 - +159.4°. The basic framework of the polysaccharide is consisted of glucose with 1→4 glycosidic linkage, and every 17 glucose residual groups there is a pendant chain of glucose molecule or glycuronic acid molecule, the ratio of glucose and glycuronic acid is 2:1, linking to the glucose in main chain with l→6 glycosidic linkage. In each mole polysaccharide the mole ratio of glucose and glycosidic acid is 53:1. The polysaccharide YCP in this invention can efficiently suppress the Heps and S180 mice-transplanted tumor. So the polysaccharide YCP in this invention can be used to prepare medicine curing tumor. It's preparation method is disclosed in this invention.
机译:一种由葡萄糖和葡萄糖醛酸组成且不包含蛋白质和核酸的多糖,分子量为1.6x 106-2.6x 106Da,α-构型端基碳,旋光度[α] Dt为+131.7- + 159.4°。多糖的基本构架由具有1→4糖苷键的葡萄糖组成,每17个葡萄糖残基上有一个葡萄糖分子或糖醛酸分子的侧链,葡萄糖与糖醛酸之比为2:1,与主链中具有1→6糖苷键的葡萄糖。在每摩尔多糖中,葡萄糖和糖苷酸的摩尔比为53:1。本发明中的多糖YCP可以有效地抑制Hep和S180小鼠移植的肿瘤。因此,本发明的多糖YCP可用于制备治疗肿瘤的药物。本发明公开了其制备方法。

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