METHODS FOR CARBON ISOTOPE LABELING SYNTHESIS BY RHODIUM-PROMOTED CARBONYLATION VIA ISOCYANATE USING AZIDES AND CARBON-ISOTOPE MONOXIDE

摘要

Methods and reagents for rhodium-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon­ isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.