Topically administrable compositions with formation of an external active ingredient depot, the production and use thereof

摘要

A topically applied composition (I) with external drug depot forming action comprises: (A) 0.01-15 % sparingly soluble active agent(s); (B) 0.5-35 % water-soluble or water-dispersible nonionic surfactant(s) with HLB value at least 8; (C) water or water-alcohol mixture; and optionally (D) 0-20 % additives. ??An Independent claim is also included for the production of (I), by adding (B) and any thermally stable additives for the aqueous phase to water at 20-85 degrees C, cooling to room temperature and adding (A) (optionally dissolved in water or aqueous alcohol) and any thermally unstable additives.