Genetically profiled cell cultures are provided along with a dataset representing the genetic profile of the cells. Also provided are methods and kits using same for the identification of the genetic basis of a trait, a disease or a state which can be directly or indirectly measured in a cell-based assay. In addition, the methods provided by the present invention can be used to: (i) identify novel drugs for the treatment and/or prevention of diseases (ii) determine population variation to drug responsiveness, efficacy, toxicity and adverse effects, and (iii) to optimize the drug lead process.
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