TREATMENT OF HEPATITIS C INFECTION BY INCREASING STAT1 METHYLATION

摘要

The present invention pertains to the signaling involved in suppression of immune function during hepatitis C infection. More specifically, this invention relates to the discovery that PP2A is involved in the inhibition of interferon alpha signaling in hepatitis C infection. Reduced STAT1 methylation and reduced interferon signaling. Restoring methylation by treatment with a methyl group donor increases interferon signaling.