DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH P21/CDC42/RAC1-ACTIVATED KINASE 1 (PAK1)

摘要

The invention provides a human PAK1 which is associated with cardiovascular diseases, dermatological diseaes, endocrinological diseases, metabolic diseases, inflammation (e.g. liver cirrhosis), gastroenterological diseases, cancer (e.g. stomach, colon, ovary or prostate tumor), hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases (e.g. Alzheimer) and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PAK1 as well as pharmaceutical compositions comprising such compounds.