METHODS AND COMPOSITIONS FOR THE GENERATION OF HUMANIZED MICE

摘要

That hommization of the non-human transgenic animal of the method provided by the present invention and composition is for generating one or more gene orders. According to the method for the present invention, to the two sides of DNA construct containing human DNA sequence by sequence from the generation of non-human animal be by recombinant bacterial cell, for example, in E. Sterilizing. The DNA construct, that is, the non-human animal with genomic DNA can be recombinated at it by generating to be then directed into non-human embryo stem cell occurs.