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METHODS AND COMPOSITIONS FOR THE GENERATION OF HUMANIZED MICE
METHODS AND COMPOSITIONS FOR THE GENERATION OF HUMANIZED MICE
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机译:产生人源化小鼠的方法和组成
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摘要
The invention provides methods and compositions for generating non-human transgenic animals that are humanized at one or more gene sequences. According to the methods of the invention, a DNA construct containing a human DNA sequence flanked by sequences from the non-human animal is generated by recombination in a bacterial cell, for example, in E. coli. The DNA construct that is produced can then be introduced into a non-human embryogenic stem cell where it can recombine with the genomic DNA of the non-human animal.
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