DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH BILE ACID G-PROTEIN-COUPLED RECEPTOR 37 (BG37)

摘要

The invention provides a human BG37 which is associated with the disorders of the gastroenterology system, disorders of the peripheral and central nervous system, urology diseases, hematology diseases, cancer diseases, inflammation and cardiovascular diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the gastroenterology system, disorders of the peripheral and central nervous system, urology diseases, hematology diseases, cancer diseases, inflammation and cardiovascular diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of BG37 as well as pharmaceutical compositions comprising such compounds.