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INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
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机译:HIV-1感染的单核细胞诱导细胞凋亡
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摘要
The present invention generally relates to the treatment or inhibition of diseases associated with HIV-1 infection. In particular, the present invention identifies a protein, which is secreted by macrophages as a result of HIV infection. The secreted protein induces apoptosis in the neuronal cells, as well as T cells and B cell. The protein is specifically expressed in the neuronal tissue of HAD patients but not in the neuronal tissue of patients with non-HIV associated dementia. Methods and compositions for decreasing, inhibiting, or otherwise abrogating neuronal cell apoptosis that leads to HIV-1 associated dementia are described.
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