TRANSGENIC ALZHEIMER'S MICE EXPRESSING APPSW GENE USEFUL FOR ALZHEIMER TREATMENT AND EARLY DIAGNOSIS

摘要

PURPOSE: A transgenic Alzheimer's mice expressing APPsw gene and a preparation method thereof are provided to show almost perfect Alzheimer symptoms and to be used in developing an Alzheimer treatment and an early diagnosis manner. CONSTITUTION: The preparation method of the transgenic Alzheimer's mice expressing APPsw(Amyloid precursor protein swedish) gene comprises the steps of: preparing a recombinant fusion gene by connecting an APPsw gene to a promoter of a NSE(Neur on-Specific Enolase) gene; microinjecting the recombinant fusion gene into a fertilized egg of a mouse; and breeding by nidating the fertilized egg into an abduct of a surrogate mother mouse.