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METHOD FOR PRODUCING PHENYL PROPIONIC ACID DERIVATIVES FROM 2-PHENYLPROPIONIC ACID BY SIMPLE PROCESSING STEPS WITH HIGH YIELD AND PURITY
METHOD FOR PRODUCING PHENYL PROPIONIC ACID DERIVATIVES FROM 2-PHENYLPROPIONIC ACID BY SIMPLE PROCESSING STEPS WITH HIGH YIELD AND PURITY
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机译:通过高产率和高纯度的简单加工步骤由2-苯丙酸制备苯丙酸衍生物的方法
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摘要
PURPOSE: Provided is a method for producing 2-(4-halomethylphenyl)propionic acid derivatives from 2-phenylpropionic acid, an easily available starting material by simple and minimized processing steps with no need of any complicated purifying steps, at high yield and purity. CONSTITUTION: The method for producing 2-(4-halomethylphenyl)propionic acid represented by formula 1 comprises a step of reacting 2-phenylpropionic acid represented by formula 2 with a hydroformylating agent in the presence of halometal and acid. In formula 1, X is Cl, Br or I. Particularly, the halometal is selected from the group consisting of sodium chloride, potassium chloride, sodium bromide, potassium bromide, sodium iodide and potassium iodide, and the acid is selected from the group consisting of sulfuric acid, HCl, acetic acid, HBr, HI, p-toluenesulfonic acid, methanesulfonic acid, trifluoroacetic acid and formic acid.
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