DIBENZYLBUTYLLACTONE LIGNAN DERIVATIVES HAVING LIVER CELL PROTECTIVE ACTIVITY WHICH IS PURIFIED FROM TORREYA NUCIFERA CORTEX AND COMPOSITIONS CONTAINING SAME FOR PROTECTING LIVER CELL AND TREATING LIVER DISEASE

摘要

PURPOSE: A pharmaceutical composition containing a dibenzylbutyllactone lignan derivative separated from the bark of Torreya nucifera(L.) Sieb. et Zucc. as an active component is provided. The dibenzylbutyllactone lignan derivative protects a liver cell from toxicity induced by carbon tetrachloride and galactosamine and effectively inhibits the proliferation of HSC2 liver. It is, therefore, effectively used in protection of the liver cell and treatment of acute, chronic liver disease. CONSTITUTION: The pharmaceutical composition contains a dibenzylbutyllactone lignan derivative represented by the formula(1) and a pharmaceutically acceptable salt. In formula, R1, R2, R3, R4 and R5 are each independently hydroxyl or methoxy groups. The dibenzylbutyllactone lignan derivative is prepared by extracting the bark of Torreya nucifera in lower alcohol at 20 to 80deg.C for 1 to 3hr, fractioning the extract with dichloromethane and then performing column chromatography.