CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN JNK1 WITH THE PEPTIDE INHIBITOR THEREOF AND METHOD FOR SCREENING REGULATORS OF HUMAN JNK1

摘要

The crystal structure of the peptide inhibitor is bound complexes; the invention is rheumatoid arthritis, Alzheimer's dementia, type 2 diabetes, and immune relevant target protein in human gave kinase 1 (JNK1 jun N-terminal kinase 1) for the disease treatment development about as, human semi-kinase 1 and peptide inhibitors is bonded composite determined in accordance with the present invention, and x- ray analysis is easy and the crystallization degree is excellent, three-dimensional structure of the crystal is rheumatoid arthritis, Alzheimer's dementia, type 2 diabetes and immune diseases humans who kinase for therapeutic research may be useful for use in the development of the activity of controlled substances 1.