ENZYMATIC CONVERSION OF RACEMIC 2-ARYLPROPIONIC ACID ESTERS TO OPTICALLY ACTIVE (S)-2-ARYLPROPIONIC ACIDS USING SUCCINYL-CYCLODEXTRINS AS THE CHIRAL SELECTOR

摘要

The present invention (R, S) -2-aryl propionic acid ester racemate (racemic (R, S) -2-aryl- propionate ester) of the lipase (lipase), or esterase (esterase) biocatalyst as a raw material by using the optically active (S) - form 2-aryl propionic acid ((S) -2-arylpropionic acids ) in the process of biological conversion, chiral selectivity (chiral selectivity) succinyl with - the addition of cyclodextrin (succinyl-cyclodextrins) by giving the (S) - form, to a method for producing a 2-aryl propionic acid with high efficiency. Succinate to add a chiral agent selected carbonyl-cyclodextrin is insoluble starting material (R, S) -2- aryl acid ester is racemic (S) with the optically active in - in combination with type and selectively formed in a water-soluble capsule and the capsule jeopche jeopche is thereby significantly improves the optical selectivity during the enzymatic reaction of a lipase or an S biocatalyst atmospheres. Also added succinyl-cyclodextrin is to significantly increase the soluble state of (R, S) -2- aryl acid ester la solubility of the racemate in an aqueous solution reaction may be added to the high concentration of the raw material. Therefore, it is possible to manufacture a high purity, high yield and high concentration according to the method of the present invention, the (R, S) -2- aryl acid ester la optically active (S) -2- aryl acid from semi body selectively.