Transformed yeast system for developing therapeutic hybrid protein drug by site-specific modification

摘要

Relates to a method for expression by using the conversion yeast systems transfected proteins only acetyl glucosyl Liberal Democratic Party attached - the invention there yen to impart regioselective the formula in the formula method of protein, is conducted by the treatment, research and industrial purposes for more particularly, by using a transformant yeast strain the gene is removed in place of the conventional sugar chain yen related to glycosylation-by inducing the glycosylation reaction in the form attached only acetyl glucosyl Liberal Democratic Party, the amino acid functional groups that make up the protein chains and is yen having a functional group distinct from - to only acetyl glucosyl Liberal Democratic party the service transformed yeast system for the production of the form of the glycoprotein added to an existing glycosylation site.