A method for quantitative analysis of multicomponent DRUGS antipyretic, analgesic, cough ACTION

摘要

FIELD: medicine, pharmacy, analytical pharmaceutical chemistry.;SUBSTANCE: invention proposes a method for simultaneous determination of composition of multicomponent medicinal preparations by reversed HPLC method with ultraviolet detector. Method is used in carrying out analysis of preparations comprising the following drugs: (1) paracetamol, propifenazone, caffeine, phenobarbital, codeine phosphate; or (2) paracetamol, ascorbic acid, codeine phosphate, phenylephrine hydrochloride, chlorphenylamine maleate; or (3) paracetamol, theophylline, caffeine, phenobarbital, ephedrine hydrochloride; or (4) codeine phosphate, nipagin, nipazol for a single stage in linear gradient regimen wherein the composition of mobile phase changes from phosphate buffer solution with pH 3.0 to its mixture with acetonitrile taken in the volume ratio = 1:1. Invention provides the complete separation of peaks of all analyzed and interfering substances and to obtain precise quantitative results.;EFFECT: improved assay method.;2 cl, 17 dwg, 16 tbl, 6 ex