PENTAFLUORSULPHANYLBENZOYLUANUANIDINE, METHOD FOR PRODUCING THEM, THEIR APPLICATION AS A MEDICINE OR DIAGNOSTIC MEDICINES, AND ALSO RECEIVING A MEDICINE

摘要

Pentafluorosulfanylbenzoylguanidine compound is new. Pentafluorosulfanylbenzoylguanidine compound of formula (I) or (II) or their salts are new. R1 = H, 1-4C alkyl, 1-4C alkoxy, halo, CN, NR10R11, -Op-(CH2)n-(CF2)o-CF3 or -(SOm)q-(CH2)r-(CF2)s-CF3; R10 and R11 = H, 1-4C alkyl or -CH2-CF3; R2 = H, halo, -CN, -SO2CH3, -(SOh)z-(CH2)k-(CF2)l-CF3, 1-6C alkyl, 3-8C cycloalkyl (in which 1 - 4 H atoms optionally replaced by fluorine), -(CH2)w-heteroaryl (optionally substituted by 1 - 3 halo, -Ox-(CH2)y-CF3, 1-4C alkoxy, 1-4C alkyl or -SO2CH3), -(CH2)t-phenyl or -O-phenyl (where each phenyl optionally substituted by 1 - 3 halo, -Ou-(CH2)v-CF3, 1-4C alkoxy, 1-4C alkyl or -SO2CH3); m and h = 0 - 2; n, o, p, q, r, s, l, u, x and z = 0 - 1; k, t and w = 0 - 4; v = 0 - 3; R3 and R4 = H or F. Independent claims are included for following: (a) preparation of (I) or (II); (b) a medicine for human, veterinary or phytoprotective use comprising (I) or (II) or a salt in combination with carrier and additives or with other active ingredients and medicaments; (c) a precursors of pentafluorosulfanylbenzoyl of formula (V). R5 = H or 1-4C alkyl.