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METHOD FOR INCORPORATION OF DSRNA OR DNA ABLE FOR PRODUCING DSRNA (VARIANTS) INTO C. ELEGANS, METHOD FOR NEGATIVE REGULATION OF EXPRESSION OF INTERSETING GENE IN C. ELEGANS (VARIANTS)
METHOD FOR INCORPORATION OF DSRNA OR DNA ABLE FOR PRODUCING DSRNA (VARIANTS) INTO C. ELEGANS, METHOD FOR NEGATIVE REGULATION OF EXPRESSION OF INTERSETING GENE IN C. ELEGANS (VARIANTS)
FIELD: molecular biology, genetic engineering.;SUBSTANCE: invention concerns characterizing and identifying the gene function using inhibition of double-stranded RNA (dsRNA). Invention proposes a method for incorporation of dsRNA or DNA able for producing dsRNA into C. elegans (variants) and a method for negative regulation of expression of interesting gene in C. elegans (variants). Proposed methods involve incorporation of dsRNA or DNA able for producing dsRNA into C. elegans wherein as result of expression inhibition of expression of target gene occurs. Invention provides carrying out investigations concerning identification of function of target genes and can be used in genetic engineering.;EFFECT: improved method for incorporation, valuable biological properties of gene.;19 dwg, 4 ex
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机译：领域：分子生物学，基因工程。;发明领域：本发明涉及通过抑制双链RNA（dsRNA）表征和鉴定基因功能。本发明提出了一种将能够产生dsRNA的dsRNA或DNA掺入秀丽隐杆线虫（变种）中的方法和对秀丽隐杆线虫（变种）中感兴趣的基因表达进行负调控的方法。提出的方法涉及将dsRNA或能够产生dsRNA的DNA掺入秀丽隐杆线虫中，其中由于表达的结果发生靶基因表达的抑制。本发明提供了有关鉴定靶基因功能的研究，可用于基因工程。效果：改进的掺入方法，基因的宝贵生物学特性。19 dwg，4 ex
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