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NANOMOLECULAR SELENIUM-TERPENE-PROTEIN AGENT AND METHOD FOR TREATMENT OF PATIENTS WITH DEPENDENCE FROM PSYCHOACTIVE SUBSTANCES
NANOMOLECULAR SELENIUM-TERPENE-PROTEIN AGENT AND METHOD FOR TREATMENT OF PATIENTS WITH DEPENDENCE FROM PSYCHOACTIVE SUBSTANCES
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机译:纳米分子萜烯蛋白制剂及治疗依赖于精神活性物质的患者的方法
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FIELD: medicine, pharmacology, pharmaceutical chemistry, proteins.;SUBSTANCE: invention relates to the development of agent and a method for treatment of patients with dependence from psychoactive substances. Nanomolecular selenium-terpene-protein agent represents two polypeptide α- and β-chains of protein joined by disulfide bridge by cysteine residues, selenium bonds between amino acids valine and leucine, and glutamic acids also and by two diselenide bonds between α- and β-chain. Sesquiterpene lactone (STL) is joined to selenoprotein molecule by carboxyl groups of by-side chains to residues of glutamic acid and/or aspartic acid, and/or to C-terminal carboxyl groups through ester bond in the molar ratio STL : selenoprotein = 4:1. Invention relates to a method for treatment of patients with dependence from psychoactive substances. Method involves administration of selenium-terpene-protein by the definite schedule. Nanomolecular selenium-terpene-protein agent exerts the simultaneous effect on both somatic body structures and immune system and on hypothalamus-hypophysis region, improved psychotic processes in patients by effect on energetic metabolism in nervous cells.;EFFECT: improved method for treatment, valuable medicinal properties of agent.;4 cl, 4 dwg, 2 ex
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机译:技术领域本发明涉及试剂的开发和治疗依赖于精神活性物质的患者的方法。纳米分子硒-萜烯蛋白试剂代表通过半胱氨酸残基,氨基酸缬氨酸和亮氨酸之间的硒键,谷氨酸也通过二硫键连接的蛋白质的两个多肽α-和β-链,以及通过α-之间的两个二硒键结合的蛋白质。和-β链。倍半萜烯内酯(STL)通过旁链的羧基与谷氨酸和/或天冬氨酸的残基和/或与C末端的羧基通过酯键以摩尔比STL:硒蛋白= 4连接到硒蛋白分子上:1。本发明涉及一种治疗依赖于精神活性物质的患者的方法。该方法涉及按照确定的时间表施用硒-萜烯-蛋白质。纳米硒硒蛋白剂同时对人体的身体结构和免疫系统以及对下丘脑-垂体区域产生作用,并通过影响神经细胞的能量代谢改善患者的精神病过程;效果:改进的治疗方法,有价值的药物剂的性质。; 4 cl,4 dwg,2 ex
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