N-(5-CYCLOPROPYL-1-QUINOLINE-5-YL-1H-PYRAZOLE-4-CARBONYL)GUANIDINE ETHANOLATES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THESE COMPOUNDS AND METHOD FOR PREPARING N-(5-CYCLOPROPYL-1-QUINOLINE-5-YL-1H-PYRAZOLE-4-CARBONYL)GUANIDINE MESYLATE SALT

摘要

FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention relates to new N-(5-cyclopropyl-1-quinoline-5-yl-1H-pyrazole-4-carbonyl)guanidine monoethanolate and hemiethanolate, to crystalline forms of these ethanolates, methods for preparing ethanolates, methods for treatment using ethanolates and mesylate salt prepared by using ethanolates. Also, invention relates to pharmaceutical composition eliciting inhibitory activity with respect to sodium-hydrogen exchange of type 1 (NHE-1) based on these compounds. Invention provides preparing new compounds and pharmaceutical compositions based on thereof for aims of prophylaxis and reducing tissue damage arisen as result ischemia or hypoxia.;EFFECT: improved preparing method, valuable medicinal properties of compounds.;15 cl, 8 tbl, 8 ex