IMIDAZOLE COMPOUNDS, METHOD FOR THEIR PREPARING, METHOD FOR INHIBITION OF ACTIVITY OF ADENOSINE DEAMINASE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: organic chemistry, biochemistry, medicine, pharmacy.;SUBSTANCE: invention relates to new imidazole compounds of the formula (I):; ;wherein R¹ represents hydrogen atom, hydroxy-, protected hydroxy-group or aryl optionally substituted with suitable substitute(s) taken among the group consisting of halogen-(lower)-alkyl, halogen atom, hydroxy-, protected carboxy-group, carbamoyl, lower alkylenedioxy- lower alkoxy-group optionally substituted with aryl and lower alkyl optionally substituted with hydroxy- or protected carboxy-group; R² represents hydrogen atom or lower alkyl; R³ represents hydroxy- or protected hydroxy-group; R⁴ represents cyano-group, (hydroxy)-iminoamino-(lower)-alkyl, carboxy-, protected carboxy-group, N-comprising heterocyclic group optionally substituted with amino-group or carbamoyl optionally substituted with suitable substitute(s) taken among the group consisting of amino-, hydroxy-group, lower alkyl, lower alkylsulfonyl and aminoimino-(lower)-alkyl optionally substituted with hydroxy-group; -A- represents -Q- or -O-Q- wherein Q means a single bond or lower alkylene, or its salt under condition that when R² means lower alkyl then R¹ represents hydroxy-, protected hydroxy-group or aryl optionally substituted with suitable substitute(s) given above, and also under condition that compound of the formula (I) doesn't represent 1-(hydroxyethyl)-4-(ethoxycarbonyl)-imidazole or 1-(2-hydroxyethyl)-imidazole 4-carboxylic acid anilide. Also, invention relates to a method for preparing these compounds, to a method for inhibition of activity of adenosine deaminase, and to a pharmaceutical composition eliciting inhibitory effect on activity of adenosine deaminase based on these compounds. Invention provides preparing new compounds and medicinal agents based on thereof used for prophylaxis and treatment of disease wherein adenosine shows the effectiveness.;EFFECT: improved inhibiting and preparing methods, valuable medicinal properties of compounds.;9 cl, 2 tbl, 32 ex