PHARMACEUTICAL COMPOSITION ELICITING IMPROVED ANTITUMOR EFFECT AND/OR REDUCED ADVERSE EFFECTS AND COMPRISING ANTITUMOR AGENT AND DERIVATIVE OF HYDROXAMIC ACID

摘要

FIELD: organic chemistry, medicine, oncology, pharmacy.;SUBSTANCE: invention relates to pharmaceutical composition comprising the known antibiotic eliciting an antitumor activity and derivative of hydroxamic acid of the formula (1) wherein the weight ratio of two active agents is (1:50)-(50:1), respectively. The composition reduces adverse effects and elicits the enhanced antitumor effect.;EFFECT: improved valuable medicinal properties of composition.;4 cl, 1 tbl, 5 ex