METHOD FOR EVALUATING THE EFFICIENCY OF PHARMACOTHERAPY AT ARTERIAL HYPERTENSION

摘要

FIELD: biochemical pharmacology.;SUBSTANCE: in blood lymphocytes both before and after therapy one should detect the activity level of succinate dehydrogenase (SDG) at the height of the test performed at dosed physical loading according to the known technique of gradually increasing loading starting from 25 W till the increase of systolic AP≥200 mm mercury column. Then one should calculate the coefficient of physical efficiency (CPE) by the following formula: where W_thr - power value (W) of patient's threshold loading in case of arterial hypertension, W_v - that of in healthy volunteers in which the desired physical loading corresponds to 200 W, t_p - duration of loading test (min) in patients with arterial hypertension, t_v - that of in healthy volunteers (min). At SDG activity level being below 20.5 and increased CPE against initial one it is possible to consider therapy conducted as efficient. The method enables to detect individual reaction to pharmacotherapy.;EFFECT: higher accuracy of evaluation.;2 ex