Microparticles containing the CGRP antagonist 1- N 2 - 3,5-dibromo-N - 4- (3,4-dihydro-2 (1H) -oxoquinazolin-3-yl) -1-piperidinyl carbonyl -D-tyrosyl -L-lysyl -4- (4-pyridinyl) -piperazine, process for their preparation and their use as inhalation powder

摘要

The invention relates to inhalable powders in the form of stable, spray-dried microparticles (embedding particles) for pulmonary or nasal inhalation, containing the CGRP antagonist 1- [N · 2 · - [3,5-dibromo-N - [[4- (3,4 -dihydro-2 (1H) oxoquinazolin-3-yl) -1-DOLLAR A piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine (A) or a physiologically acceptable Salt thereof and one or more excipients, process for producing such microparticles, and use for the preparation of a powder inhalant for the treatment of headache, migraine and cluster headache. DOLLAR F1