photolabile cumarinylmethylester of cyclic nucleotides, methods for their production and their use

摘要

The invention relates to new photolabile coumarinylmethyl esters of cyclic nucleotides of general formula I wherein RSUP1 /SUPrepresents hydrogen, bromine or p-chlorophenylthio RSUP4 /SUPrepresents 7-carboxymethoxy, 6,7-, 5,7- or 7,8-bis-(carboxymethoxy), 7-CSUB1/SUB-CSUB3/SUB-alkoxycarbonylmethoxy, 6,7-bis(CSUB1/SUB-CSUB3/SUB-alkoxycarbonylmethoxy), 5,7-bis(CSUB1/SUB-CSUB3/SUB-alkoxy-carbonylmethoxy), or 7,8-bis(CSUB1/SUB-CSUB3/SUB-alkoxycarbonylmethoxy), RSUP2 /SUPrepresents -NHSUB2 /SUBand RSUP3 /SUPis hydrogen (adenine residue), or RSUP2 /SUPrepresents -OH and RSUP3 /SUPrepresents NHSUB2 /SUB(guanine residue) The inventive compounds are biologically inactive and exhibit high solubility in aqueous buffer solutions, high efficiency in photocleavage and rapid kinetics of liberation, together with high resistance to solvolysis.