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ECHINOCANDIN PHARMACEUTICAL SUMMARIES

机译:棘皮CAN制药概述

摘要

Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
机译:描述了在无毒水性溶剂中包含棘皮菌素化合物或棘皮菌素/碳水化合物复合物和药学上可接受的形成胶束的表面活性剂的药物制剂,从而使棘皮菌素化合物的增溶作用最优化并且保持溶液冻干的能力。溶液和冻干制剂均具有增加的稳定性。可以任选地将增量剂,张度剂缓冲剂和/或稳定剂添加到制剂中以进一步增强制剂的稳定性。

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