TRP-226 MUTANTS OF HUMAN GLANDULAR CALLICENE-1 (hK2)

摘要

A new form of human glandular kallikrein-1 (hK2) found from cloning a prepro-hK2 cDNA from a human protrate cancer tissue cDNA library. The new form differs in sequence from the prior art form in that Arg226 is substituted by Trp. A baculovirus expression vector is described for obtaining hK2 proteins, including Arg226-hK2 as an active mature protein directly from a culture medium.