1-(2-NAPHTHYL) UND 1-(2-AZANAPHTHYL)-4-(1-PHENYLMETHYL)PIPERAZINE ALS DOPAMIN D4 SUBTYPE LIGANDEN

摘要

Disclosed are compounds of formula: (I) or pharmaceutically acceptable addition salts thereof, wherein: X, Y and Z are the same or different and represent optionally substituted carbon or nitrogen; R1 and R2 independently represent organic or inorganic substituents; R3 and R4 are variables independently representing inorganic or organic substituents; A represents C1-C4 alkylene; and R5, R6 and R7 independently represent hydrogen or C1-C6 alkyl, which compounds bind selectively with high affinity to the dopamine D4 receptor subtype and are therefore of use in treatment of various neuropsychological disorders.