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METHOD FOR MANUFACTURING AN ACTIVE MOLECULE VECTOR APPLICABLE IN THE FIELD OF DIFFUSION OF ACTIVE PRINCIPLES AND VECTOR OBTAINED
METHOD FOR MANUFACTURING AN ACTIVE MOLECULE VECTOR APPLICABLE IN THE FIELD OF DIFFUSION OF ACTIVE PRINCIPLES AND VECTOR OBTAINED
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机译:制造有源原理和获得的矢量的领域中的有源分子矢量的制造方法
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摘要
A method for the production of a vector for active molecules by polycondensation of (A) a diamine in which the amino groups are separated by at least 4 carbons with (B) glutaraldehyde involves carrying out the reaction at pH 6.5-7.5. A method for the production of a vector for active molecules for use in biomedical applications involves (a) diluting a monomer containing at least two NH2 groups separated by at least 4 carbons with water, (b) adjusting to pH 6.5-7.5, (c) adding glutaraldehyde, (d) reacting by polycondensation with imine formation and (e) working up the polymer obtained, i.e. poly-(monomer-G), where G represents reduced glutaraldehyde. An Independent claim is also included for vectors as above, comprising poly-(ornithine-G), poly-(L-lysine-G) or poly-(citrulline-G) (i.e. poly-(monomer-G)) grafted with active molecules such as fatty acids, antioxidants, vitamins, hormones, medicaments or neuro-transmitters to provide bacteriostatic, anti-allergenic, anti-parasite, anti-predator, antifungal, anti-inflammatory or immunomodulant activity.
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