New molecular spacer arm, useful for attaching compounds, especially sugars, to analytical chips, includes double bond for selective cleavage

摘要

A molecular spacer arm for attaching (bio)molecules to analytical chips, is new. Molecular spacer arm of formula (I) for attaching (bio)molecules to analytical chips. [mo]-X 4-[X 3(R 3)] p-CH 2-N(Gp)-[X 2(R 2)] m-Z 2=Z 1-CH 2-[X 1(R 1)] n-X 0-[Sup] (I) X 0 and X 4 = C, O, N, S, Se, P, As or Si; X 1, X 2 and X 3 = as X 0 or also 2-20C (hetero)aryl; Z 1 and Z 2 = C-R, Si-R, C, N, P or As; R = 1-40C alkyl; R 1, R 2 and R 3 = hydrogen, or 2-20C alkyl or (hetero)aryl; Gp = protecting group for secondary amino or a molecule that participates in the functioning of the spacer arm; n, m and p = integer 1 or more, especially 1-40; Sup = hydrogen or a solid silanized support on which the spacer can be attached covalently; mo = hydrogen or molecular unit that is to be fixed covalently to the support, through the spacer An independent claim is also included for a method of covalent attachment of mo to a support through a spacer arm.