CALCIUM CHANNEL, VOLTAGE-DEPENDENT, P/Q TYPE, ALPHA 1a SUBUNIT GENE-MUTANT RAT

摘要

PPROBLEM TO BE SOLVED: To provide a new model animal for Cacna1a-related diseases useful for screening preventive or therapeutic materials for the Cacna1a associated diseases. PSOLUTION: A method for producing a Cacna1a-related disease model nonhuman vertebrate including modification of a chromosome to express a specific mutant Cacna1a polypeptide is provided. The Cacna1a-related disease model nonhuman vertebrate produced by the method, especially the Groggy rat is useful for screening preventive or therapeutic materials for the Cacna1a-related diseases or methods for treating the diseases. PCOPYRIGHT: (C)2006,JPO&NCIPI