DIMERIC THROMBOPOIETIN PEPTIDE MIMETICS BINDING TO Mpl RECEPTOR AND HAVING PLATELET-PRODUCING ACTIVITY

摘要

PPROBLEM TO BE SOLVED: To provide a compound having a biological activity stimulating the production of platelets (platelet-producing activity) and/or a biological activity stimulating platelets precursors, especially megakaryocyte (megakaryocyte-producing activity). PSOLUTION: Provided is a group of compounds, especially peptides and polypeptides, capable of binding to and triggering a transmembrane signal through, i.e., activating, a c-Mpl receptor, which is the same receptor that mediates the activity of endogenous thrombopoietin (TPO). PCOPYRIGHT: (C)2006,JPO&NCIPI