SINGLE ANTIBIOTIC/PLURAL ANTIBIOTICS-CONTAINING BONE SUBSTITUTE MATERIAL WITH DELAYED ACTIVE SUBSTANCE RELEASE

摘要

PPROBLEM TO BE SOLVED: To provide an inexpensive and easily maufacturable single antibiotic/plural antibiotics containing substitute material with delayed active substance release. PSOLUTION: This single antibiotic/plural antibiotics containing bone substitute material is composed of a compacted mixture of granules of calcium sulfate dihydrate, calcium carbonate and at least one representative of the aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, the nitroimidazoles, the fluorochinolone antibiotics and the oxazolidinone antibiotics, the steroid antibiotics, the antiseptic agents and the fungicidal/fungistatic antibiotics, the granules are partly or entirely coated with a layer of glycerol tripalmitate and/or glycerol tristearate and/or glycerol trilaurate and/or 1-hexadecyl alcohol, the layer connects the granules with each other. PCOPYRIGHT: (C)2006,JPO&NCIPI