METHOD FOR EVALUATING SUBSTANCE CAPABLE OF ACTING ON ENDOPLASMIC RETICULUM-INDUCING AND/OR AMYLOID-amp;beta;-INDUCING APOPTOSIS

摘要

PROBLEM TO BE SOLVED: To provide a means capable of acting (for example, control, promotion) on apoptosis on the basis of a route different from an apoptosis signal communication route in mitochondria.;SOLUTION: A method for evaluating a substance capable of acting on endoplasmic reticulum-inducing and/or amyloid-β-inducing apoptosis comprises bringing a test substance into contact with a cell expressing procaspase-4. A system for evaluating the substance. A medicinal composition contains as an active ingredient a substance which is evaluated by the evaluation method and can inhibit diseases caused in relation to the above-mentioned-endoplasmic reticulum-inducing and/or amyloid-β-inducing apoptosis or the advance of the diseases.;COPYRIGHT: (C)2006,JPO&NCIPI