The cerebrovascular spasm remedy medicine which features the cerebrovascular spasm remedy

摘要

PROBLEM TO BE SOLVED: To obtain a treatment preparation that can inhibit cerebral blood vessel twitching after cerebral hemorrhage, particularly subarachnoid hemorrhage and can promote the removal of hematoma by using activated protein C (abbreviated to APC hereinafter) as an active ingredient. SOLUTION: This therapeutic agent includes APC as an active ingredient. In a preferred embodiment, the APC is particularly human blood-originating APC or human APC given by the gene technology. This blood originating APC is obtained by, for example, purifying protein C in affinity chromatography using anti-protein C-antibody, preferably the monoclonal antibody from human plasma and activating the purified protein C with human thrombin and purifying the activated protein C with the cationic ion-exchange chromatography. This preparation is preferably used as an injection preparation. The daily dose of this preparation is 0.5-10 mg/adult in the case of administration into the cistern.