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Method of delivery of the active agent to the occlusal surface of the tooth and the solid unit dosage form chewable

机译:将活性剂递送至牙齿的咬合表面的方法和可咀嚼的固体单位剂型

摘要

Human or for topical oral administration to animals other relates to oral care compositions and methods invention,: a. Water soluble hydrophilic gums, water soluble hydrophilic polymers, and are selected from the group consisting of mixtures thereof, a retention agent of about 40 weight percent to about 1 weight% of the composition, wherein the retention agent is water and b; retention agent or has the property of hydrating upon exposure to saliva, to form a complete hydrated mass to provide a retention index of about 1 to about 4 the composition thereby. Including topical oral care carriers of a safe and effective amount, wherein, a non-cariogenic, wherein the composition is a chewable solid unit dosage form, wherein the composition comprises water-insoluble particulate of about 65 wt% I include the substance classes. Furthermore, regarding oral care dentifrice composition invention: a. Water solubility of about 1g / 30g less than 25 ℃, water-insoluble particulate retention agent to about 65 weight percent to about 30 weight% of the composition; b. Oral care actives of a safe and effective amount; c. Surfactants are safe and effective amount; d. Comprise buffering agents in a safe and effective amount, wherein said composition is a chewable dentifrice solid unit for dosage forms, non-foaming, are non-cariogenic, wherein the composition comprises from about 1 to about 4 I have a retention index of.
机译:人或动物的局部口服给药还涉及本发明的口腔护理组合物和方法:a。水溶性亲水胶,水溶性亲水聚合物和选自它们的混合物,占组合物的约40重量%至约1重量%的保持剂,其中该保持剂为水和b;和保留剂或具有在暴露于唾液时水合的性质,以形成完全水合的物质,从​​而为组合物提供约1至约4的保留指数。包括安全有效量的局部口腔护理载体,其中,非致龋的,其中组合物是可咀嚼的固体单位剂型,其中组合物包含约65重量%的水不溶性颗粒,包括物质类别。此外,关于口腔护理洁齿剂组合物的发明:水溶性约1g / 30g,小于25℃,不溶于水的颗粒状保留剂占组合物的约65%(重量)至约30%(重量); b。安全有效量的口腔护理活性成分; C。表面活性剂安全有效量; d。以安全和有效的量包含缓冲剂,其中所述组合物是用于剂型的可咀嚼的洁齿剂固体单元,非起泡,不致龋齿,其中所述组合物包含约1至约4 I的保留指数。

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