Process for the enantioselective preparation of both enantiomers of 10,11-dihydro-10-hydroxy-5H-dibenz b, f azepine-5-carboxamide and its novel crystalline form

摘要

The invention relates to a novel process for the manufacture of substituted enantiopure 10hydroxy-dihydrodibenz[b,f]azepines (Ia), (Ib) wherein each of RSUP1 /SUPand RSUP2/SUP, independently, are hydrogen, halogen, amino or nitro; and each of RSUP3 /SUPand RSUP4/SUP, independently, are hydrogen or CSUB1/SUB-CSUB6/SUBalkyl; by transfer hydrogenation of 10-oxo-dihydrodibenz[b,f]azepines; and to novel catalysts of formula (III'a) and (III'b) wherein M is Ru, Rh, Ir, Fe, Co or Ni; LSUB1 /SUBis hydrogen; LSUB2 /SUBrepresents an aryl or aryl-aliphatic residue; and the further radicals have the meanings as defined herein; and to new crystal forms of both enantiomers of 10,11-dihydro-10 hydroxy-5Hdibenz[b,f]azepine-5-carboxamide, obtainable by the new processes, their usage in the production of pharmaceutical preparations, new pharmaceutical preparations comprising these new crystal forms and/or the use of these new crystal forms in the treatment of disorders such as epilepsy, or in the production of pharmaceutical formulations which are suitable for this treatment.