Substituted alkyl-pyridazinones for the treatment of memory and learning impairment

摘要

The compounds of the general Formula I, wherein RSUP1 /SUPstands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, RSUP2 /SUPis hydrogen or lower alkyl; n is 1, 2 or 3; RSUP3 /SUPis hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or RSUP3 /SUPand Z together with the intermediate atoms form piperazino ring; Q and W independently from each other stands for -CH- or -N-; and RSUP4/SUP, RSUP5 /SUPand RSUP6 /SUPcan be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or RSUP4 /SUPand RSUP5 /SUPtogether form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.