CROSS-β STRUCTURE COMPRISING AMYLOID-BINDING PROTEIN, METHOD FOR DETECTING CROSS-β STRUCTURE, METHOD FOR MODULATION OF CROSS-β STRUCTURE FIBRILLATION, AND METHOD FOR MODULATION OF TOXICITY TRANSPORTED BY CROSS-β STRUCTURE

摘要

The invention relates to cross- beta structures and the biological role of these cross- beta structures. Methods for modulating extracellular protein degradation and/or protein clearance or for diminishing plaques involved in conformational diseases by modulating cross- beta structure formation and/or tissue plasminogen activator (tPA)-like activity are disclosed, as well as diagnostic methods by visualising cross- beta structures.