The present invention provides monoclonal antibodies that inhibit human VEGF receptor Flt-1 and human VEGF receptor Flt-1, a monoclonal antibody that responds immunically to cells that have been expressed on the cell surface, and a human VEGF receptor Flt-1 to inhibit human VEGF receptor Flt-1. In addition, diagnosis and treatment of the disease which progresses by the abnormal angiogenesis such as arthritis, metastasis formation of the solid tumor using the monoclonal antibody, arthritis in the chronic joint rheumatism, diabetic retinopathy, prematurity retinopathy, and dry tissue are provided.
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