Gene therapy vector and method for quantifying target protein in mammals or cultured cells to which the gene therapy vector is administered

摘要

Disclosed is a gene therapy vector that can monitor the blood concentration of a target protein at the time of gene therapy with higher sensitivity, and that the labeled peptide has no physiological effect and is not immunogenic in many animals. Yes. A gene therapy vector has a structure in which a nucleic acid encoding a fusion protein of a C-terminal 19-29 amino acid peptide region of glucagon and a target protein region to be produced in the body is incorporated into an expression vector for mammalian cells.