Medicine controlled release carrier

摘要

Without obstructing the biological activity of the protein or peptide be able to enclose the purpose of this invention, in high enclosure ratio, it is to offer the safe protein or the controlled release formulation of peptide completely with biodegradation characteristic. This invention, hyaluronic acid (HA) the hyaluronic acid derivative which introduces the hydrazide basis, under protein or peptide coexisting, builds a bridge in the solution below pH6, is related to the production method of the hyaluronic acid derivative gel which features that haidorogeru it does. With this invention, while biological activity of the protein and peptide is maintained these efficiency enclosure, and controlled release to inside the particular gel become possible.