Pharmaceutical composition for controlled release of beta-lactam antibiotics in combination with beta-lactamase inhibitors

摘要

The invention relates to a pharmaceutical composition containing a β-lactam antibiotic and/or a pharmaceutically tolerable salt thereof in the form of coated pellets that may optionally contain a β-lactamase inhibitor and/or a pharmaceutically tolerable salt thereof, some or all pellets comprising coatings that dissolve at different pH values depending on the composition of said coatings. This pharmaceutical composition allows the blood plasma level of the β-lactam antibiotic and/or a pharmaceutically tolerable salt thereof to remain above 2 μg/ml for at least 12 hours within a period of 24 hours if administered twice a day.