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METHODS FOR THE DIAGNOSIS AND TREATMENT OF METASTATIC PROSTATE TUMORS
METHODS FOR THE DIAGNOSIS AND TREATMENT OF METASTATIC PROSTATE TUMORS
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机译:诊断和治疗转移性前列腺癌的方法
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摘要
The present invention is directed to methods for the identification of a prostate cancer cell that has metastatic potential or a cell that is or is derived from a secondary prostate tumor metastasis by screening for the expression of flt-4, the cellular receptor of vascular endothelial growth factor-C and -D (“VEGF-C”, “VEGF-D”). The present invention is also directed to methods for treating, inhibiting or preventing secondary prostate tumor metastases by inhibiting the expression or activity of flt-4, e.g., inhibiting flt-4: VEGF-C/D complex formation (binding), by administration of a therapeutic. Compositions useful in such methods are also provided.
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