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Use of at least one $g(a)62 casein peptide with angiotensin i converting enzyme inhibiting activity for preparing medicines, food products and food complements

机译：至少一种带有血管紧张素i转化酶抑制活性的$ g（a）62酪蛋白肽在制备药物，食品和食品补品中的用途

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The invention relates to the use in the preparation of medicines having activity of the antihypertensive type, useful for treating or preventing hypertension, of one or more peptides having inhibiting activity on ACE with IC₅₀values of the order of or less than 60 μM, selected from the group of peptides having the following amino acid sequences: <TableGroup align="left" colSep="0" cols="3" rowSep="0"><Colspec align="left" colName="1" colWidth="140PT"/><Colspec align="left" colName="2" colWidth="77PT"/><Colspec align="left" colName="3" colWidth="0PT"/><Tbody valign="top"><Row><entry/></Row><Row><entry>Thr-Val-Tyr</entry><entry>(SEQ ID No.: 1)</entry><entry/></Row><Row><entry/></Row><Row><entry>Asn-Met-Ala-Ile-Asn-Pro-Ser-Lys</entry><entry>(SEQ ID No.: 2)</entry></Row><Row><entry/></Row><Row><entry>Phe-Ala-Leu-Pro-Gln-Tyr</entry><entry>(SEQ ID No.: 3)</entry></Row><Row><entry/></Row><Row><entry>Phe-Pro-Gln-Tyr-Leu-Gln-Tyr</entry><entry>(SEQ ID No.: 4)</entry></Row><Row><entry/></Row><Row><entry>Phe-Ala-Leu-Pro-Gln-Tyr-Leu-Lys</entry><entry>(SEQ ID No.: 5)</entry></Row><Row><entry/></Row><Row><entry>Asn-Met-Ala-Ile-Asn-Pro</entry><entry>(SEQ ID No.: 6)</entry></Row><Row><entry/></Row><Row><entry>Phe-Ala-Leu-Pro.</entry><entry>(SEQ ID No.: 7)</entry></Row></Tbody></TableGroup></TableFormula></Table>The invention also relates to a pharmaceutical composition containing as its active principle an effective quantity of one or more of the above-cited peptides in combination with a pharmaceutically acceptable vehicle. The invention also relates to a food product, in particular suitable for supplementing the diet of people subject to hypertension or seeking to prevent the appearance thereof, containing an effective quantity of one or more of the above-cited peptides, in combination with food supports, in particular proteins, lipids, or carbohydrates. Such a food product may also include at least one of the peptides having the following amino acid sequences: <Table id="TABLE-US-00002"><TableFormula><Title/><TableGroup align="left" colSep="0" cols="3" rowSep="0"><Colspec align="left" colName="1" colWidth="147PT"/><Colspec align="left" colName="2" colWidth="70PT"/><Colspec align="left" colName="3" colWidth="0PT"/><Tbody valign="top"><Row><entry/></Row><Row><entry>Ala-Leu-Asn-Glu-Ile-Asn-Gln-Phe-</entry><entry>(SEQ ID No.: 8)</entry><entry/></Row><Row><entry>Tyr-Gln-Lys</entry></Row><Row><entry/></Row><Row><entry>Ala-Leu-Asn-Glu-Ile-Asn-Gln-Phe-</entry><entry>(SEQ ID No.: 9)</entry></Row><Row><entry>Tyr</entry></Row><Row><entry/></Row><Row><entry>Tyr-Leu.</entry><entry>(SEQ ID No.: 10)</entry></Row></Tbody></TableGroup></TableFormula></Table> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>本发明涉及用于制备具有抗高血压类型的活性的药物的用途，所述抗高血压类型的用于治疗或预防高血压的一种或多种对ACE具有抑制活性的肽具有IC <Sub> 50 </ Sub>值，约为或小于60μM，选自具有以下氨基酸序列的肽：<Table id =“ TABLE-US-00001”> <TableFormula> <Title /> <TableGroup align =“ left” colSep =“ 0” cols =“ 3” rowSep =“ 0”> <Colspec align =“ left” colName =“ 1” colWidth =“ 140PT” /> <Colspec align =“ left” colName =“ 2” colWidth =“ 77PT” /> <Colspec align =“ left” colName =“ 3” colWidth =“ 0PT” /> < Tbody valign =“ top”> <行> <entry /> </ Row> <行> <entry> Thr-Val-Tyr </ entry> <entry>（SEQ ID No .: 1）</ entry> <entry /> </ Row> <Row> <entry /> </ Row> <Row> <entry> Asn-Met-Ala-Ile-Asn-Pro-Ser-Lys </ entry> <entry>（SEQ ID No. ：2）</ entry> </ Row> <Row> <entry /> </ Row> <Row> <entry> Phe-Ala-Leu-Pro-Gln-Tyr </ entry> <entry>（SEQ ID No 。：3）</ entry> </ Row> <Row> <entry /> </ Row> <Row> <entry> Phe-Pro-Gln-Tyr-Leu-Gln-Tyr </ entry> <entry>（ SEQ ID No .: 4）</ entry> </ Row> <Row> <entry /> </ Row> <Row> <entry> Phe-Ala-Leu-Pro-Gln-Tyr-Leu-Lys </ entry > <entry>（SEQ ID No .： 5）</ entry> </ Row> <Row> <entry /> </ Row> <Row> <entry> Asn-Met-Ala-Ile-Asn-Pro </ entry> <entry>（SEQ ID No .: 6）</ entry> </ Row> <Row> <entry /> </ Row> <Row> <entry> Phe-Ala-Leu-Pro。</ entry> <entry>（SEQ ID No .: 7）</ entry> </ Row> </ Tbody> </ TableGroup> </ Tabl eFormula> </ Table>本发明还涉及一种药物组合物，其包含有效量的一种或多种上述肽与药学上可接受的载体组合作为其活性成分。本发明还涉及一种食品，特别适合于补充患有高血压或试图防止其出现的人们的饮食，其包含有效量的一种或多种上述被引用的肽，并与食品支持物组合，特别是蛋白质，脂质或碳水化合物。这样的食品还可以包括具有以下氨基酸序列的至少一种肽：<Table id =“ TABLE-US-00002”> <TableFormula> <Title /> <TableGroup align =“ left” colSep =“ 0” cols =“ 3” rowSep =“ 0”> <Colspec align =“ left” colName =“ 1” colWidth =“ 147PT” /> <Colspec align =“ left” colName =“ 2” colWidth =“ 70PT” /> <Colspec align =“ left” colName =“ 3” colWidth =“ 0PT” /> < Tbody valign =“ top”> <行> <entry /> </ Row> <行> <entry> Ala-Leu-Asn-Glu-Ile-Asn-Gln-Phe-</ entry> <entry>（SEQ ID编号：8）</ entry> <entry /> </ Row> <Row> <entry> Tyr-Gln-Lys </ entry> </ Row> <Row> <entry /> </ Row> <Row> <entry> Ala-Leu-Asn-Glu-Ile-Asn-Gln-Phe-</ entry> <entry>（SEQ ID No .: 9）</ entry> </ Row> <Row> <entry> Tyr < /entry></Row><Row><entry/></Row><Row><entry>Tyr-Leu.</entry><entry>(SEQ ID No .: 10）</ entry> </ Row > </ Tbody> </ TableGroup> </ TableFormula> </ Table> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33">著录项</h2> <div class="getdents"> <ul> <li> <p><span>公开/公告号</span><span>US2006234942A1</span></p> <p><span>专利类型</span><span></span></p> </li> <li> <p><span>公开/公告日</span><span>2006-10-19</span></p> <p><span>原文格式</span><span>PDF</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">申请/专利权人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=JEROME TAUZIN&option=232">JEROME TAUZIN;</a><a href="/search.html?doctypes=12_13&sertext=LAURENT MICLO&option=232">LAURENT MICLO;</a><a href="/search.html?doctypes=12_13&sertext=CATHERINE LEFRANC&option=232">CATHERINE LEFRANC;</a><a href="/search.html?doctypes=12_13&sertext=JEAN-FRANCOIS BOUDIER&option=232">JEAN-FRANCOIS BOUDIER;</a><a href="/search.html?doctypes=12_13&sertext=JEAN-LUC GAILLARD&option=232">JEAN-LUC GAILLARD;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请/专利号</span><span style="width: 250px;">US20050519164</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">发明设计人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=JEROME TAUZIN&option=202">JEROME TAUZIN;</a><a href="/search.html?doctypes=12_13&sertext=LAURENT MICLO&option=202">LAURENT MICLO;</a><a href="/search.html?doctypes=12_13&sertext=CATHERINE LEFRANC&option=202">CATHERINE LEFRANC;</a><a href="/search.html?doctypes=12_13&sertext=JEAN-FRANCOIS BOUDIER&option=202">JEAN-FRANCOIS BOUDIER;</a><a href="/search.html?doctypes=12_13&sertext=JEAN-LUC GAILLARD&option=202">JEAN-LUC GAILLARD;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请日</span><span>2003-06-24</span></p> </li> <li> <p style="width: 100%;"><span>分类号</span><span style="width: 80%;">A61K38/10;A61K38/08;A61K47;</span> </p> </li> <li> <p style="width: 100%;"><span>国家 </span><span style="width: 93%;">US</span></p> </li> <li><p style="width: 100%;"> <span >入库时间</span> <span>2022-08-21 21:47:40</span></p> </li> </ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity"> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul > <li >专利</li> <li >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120700388.html">具有酪蛋白磷酸肽和抗血管紧张素转化酶肽的成熟干酪及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN1887098B </span> <span> . 2010.12.15</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120592655.html">具有酪蛋白磷酸肽、抗血管紧张素转化酶肽和低聚半乳糖乳清粉的制备方法</a> <b>[P]</b> . <span> 中国专利： CN1903052B </span> <span> . 2010.04.28</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130442160396.html">USE OF AT LEAST ONE $G(A)LESS THANSBGREATER THAN62LESS THAN/SBGREATER THAN CASEIN PEPTIDE WITH ANGIOTENSIN I CONVERTING ENZYME INHIBITING ACTIVITY FOR PREPARING MEDICINES, FOOD PRODUCTS AND FOOD COMPLEMENTS</a> <b>[P]</b> . <span> AU2003255691A1 </span> <span> . 2004-01-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译： </span>酪蛋白肽至少比酪蛋白肽少/ $ G（A）脂肪含量少/血管紧张素I转化酶抑制活性，可用于制备药物，食品和食品添加剂 </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130440128211.html">Use of at least one casein (alpha) s2 peptide with angiotensin converting enzyme inhibiting activity for the preparation of medicaments, foods and food supplements</a> <b>[P]</b> . <span> BR0312214A </span> <span> . 2005-04-12</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译： </span>具有血管紧张素转化酶抑制活性的至少一种酪蛋白（α）s2肽在制备药物，食品和食品补充剂中的用途 </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130441267034.html">USE OF AT LEAST ONE S2 CASEIN PEPTIDE WITH ACTIVITY INHIBITOR OF ENGIOTENSIN I CONVERTING ENZYME FOR THE PREPARATION OF MEDICAMENTS, FOODS AND FOOD SUPPLEMENTS</a> <b>[P]</b> . <span> 法国专利： FR2841473A1 </span> <span> . 2004-01-02</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译： </span>至少有一个S2酪蛋白肽与活性蛋白的抑制剂I转化酶在制备药物，食品和食品中的用途 </p> </li> </ul> <ul 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class="enjiyixqcontent" href="/academic-journal-cn_chemical-research-chinese-universities_thesis/0201264773643.html">Liquid Chromatographic Assay of Peptides Activity with Inhibiting Angiotensin Converting Enzyme</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=LIU Jing-bo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">LIU Jing-bo,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=YU Zhi-peng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">YU Zhi-peng,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=ZHAO Wen-zhu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">ZHAO Wen-zhu,</a> <a href="/journal-foreign-10959/" target="_blank" rel="nofollow" class="tuijian_authcolor">高等学校化学研究（英文版） .</a> <span>2010</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-integrative-agriculture_thesis/020126242572.html">A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from the Milk Casein: Virtual Screening and Docking Studies</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=WANG Zhan-li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">WANG Zhan-li,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=ZHANG Sai-sai&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">ZHANG Sai-sai,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=WANG Wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">WANG Wei,</a> <a href="/journal-foreign-7366/" target="_blank" rel="nofollow" class="tuijian_authcolor">农业科学学报（英文版） .</a> <span>2011</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-northeast-agricultural-university-english-edition_thesis/0201275438475.html">Drying Technology of Angiotensin Converting Enzyme Inhibitory Peptide Derived from Bovine Casein</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=JIANG Zhanmei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">JIANG Zhanmei,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Hue Guicheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hue Guicheng,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=TIAN Be&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">TIAN Be </a> <a href="/journal-foreign-7229/" target="_blank" rel="nofollow" class="tuijian_authcolor">东北农业大学学报（英文版） .</a> <span>2009</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-northeast-agricultural-university-english-edition_thesis/0201268402219.html">Drying Technology of Angiotensin Converting Enzyme Inhibitory Peptide Derived from Bovine Casein</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=JIANG Zhanmei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">JIANG Zhanmei,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=HUO Guicheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">HUO Guicheng,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=TIAN Bo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">TIAN Bo </a> <a href="/journal-foreign-7229/" target="_blank" rel="nofollow" class="tuijian_authcolor">东北农业大学学报：英文版 .</a> <span>2009</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-279476_thesis/0705016136854.html">Synthesis and Activity Determination of Angiotensin Converting Enzyme Inhibitors Derived from αs1-casein Protein</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Ren Yalin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ren Yalin,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Cong Yanjun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Cong Yanjun,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Chen Cunshe&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chen Cunshe </a> <a href="/conference-foreign-279476/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Conference on Future Materials Engineering and Industry Application .</a> <span>2012</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061157977.html">Angiotensin converting enzyme inhibitory peptides released from the hydrolysate of casein and the milk fermented by Lactobacillus casei ADA03.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Kusump, Sirinda.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kusump, Sirinda. </a> <span>2006</span> </span> </div> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/04000897968.html">IgE-Mediated Anaphylaxis to Foods Venom and Drugs: Influence of Serum Angiotensin Converting Enzyme Levels and Genotype</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=V. A. Varney&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">V. A. Varney,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=A. Warner&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">A. Warner,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=A. Ghosh&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">A. Ghosh,</a> <span>2012</span> </span> </div> </li> <li> <div> <b>9. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/010006829789.html ">Binding mechanism of pharmacological inhibitors and antihypertensive food peptides to human somatic angiotensin I-converting enzyme (ACE)</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Zeder-Lutz, Gabrielle&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zeder-Lutz, Gabrielle,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Zidane, Faïza&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zidane, Faïza,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Legrani, Kaddidja&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Legrani, Kaddidja,</a> <span>2014</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" 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