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Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
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机译:通过无创体内电穿孔增强裸露DNA向皮肤的递送
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摘要
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
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