首页>
外国专利>
Computer systems and methods for inferring causality from cellullar constituent abundance data
Computer systems and methods for inferring causality from cellullar constituent abundance data
展开▼
机译:从细胞组成丰度数据推断因果关系的计算机系统和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods for determining whether a molecule affects a disorder are provided. A cell from an organism is contacted with the molecule, or the molecule is expressed within the cell. A determination is made as to whether the RNA or protein expression in the cell of at least one open reading frame is changed relative to the expression of the reading frame in the absence of the molecule. Each such open reading frame is regulated by a promoter native to SEQ ID NOS: 5-9, 11-12, 14, 16, 18, 20-21, 23, 25, 27, 29, 31, 33 or homologs of the foregoing. A determination is made as to whether the molecule affects the disorder when the RNA or protein expression of the at least one reading frame is changed. Alternatively, a determination is made that the molecule does not affect the disorder when the RNA or protein expression of the at least one reading frame is unchanged.
展开▼
机译:提供了确定分子是否影响疾病的方法。来自生物体的细胞与分子接触,或者该分子在细胞内表达。确定至少一个开放阅读框在细胞中的RNA或蛋白质表达相对于不存在分子时阅读框的表达是否发生改变。每个这样的开放阅读框由SEQ ID NOS:5-9、11-12、14、16、18、20-21、23、25、27、29、31、33天然的启动子或前述的同源物调节。 。当改变至少一个阅读框的RNA或蛋白质表达时,确定该分子是否影响疾病。备选地,当至少一个阅读框的RNA或蛋白质表达不变时,确定该分子不影响该疾病。
展开▼