Alpha(1,3)-galactosyltransferase null cells, methods of selecting and alpha(1,3)-galactosyl transferase null swine produced therefrom

摘要

The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides a method of selecting GGTA 1 null cells, a viable GGTA 1 null swine, methods for making such swine, and methods of using cells, tissues and organs of such swine for xenotransplantation.